ProMIS Neurosciences Reports New Milestones in Potential Therapeutic Approaches for Amyotrophic Lateral Sclerosis (ALS)

 

Almost all cases of ALS, and about half of cases of the related disease frontotemporal degeneration (FTD), feature intracellular aggregates of the protein TDP-43 in the brain and spinal cord. Although normal TDP-43 protein is critical for the survival of neurons, misfolded aggregates of TDP-43 possess many neurotoxic activities and are believed to be a driver of disease. Using its discovery platform, ProMIS generated high-affinity monoclonal antibodies that are selective for the misfolded, toxic form of TDP-43 and has nominated monoclonal antibody PMN267 as the lead candidate based on its binding profile and activity in cell systems.  Recent data generated by two independent sources have now provided additional support for the therapeutic potential of PMN267. 

 

Dr. Gene Yeo’s laboratory at the University of California San Diego has shown that an “intrabody” version of PMN267 delivered inside cells via a gene therapy vector significantly reduced the amount of misfolded TDP-43 aggregates in human motor neurons derived from ALS patients, the cell type predominantly affected in ALS.

 

In an aggressive mouse model of ALS/FTD conducted at a contract research organization, testing of PMN267 as an injectable antibody treatment also produced evidence for protection against disability.  These results are in line with reports indicating that antibodies with effector function can be taken up inside neurons and trigger degradation of their target, in this case toxic TDP-43 aggregates.

 

ProMIS CSO Dr. Neil Cashman was pleased by the results, saying “these are encouraging findings that support the activity of PMN267 as a conventional antibody and as an intrabody constructed from PMN267”. Dr. Larry Altstiel, ProMIS’ CMO, said “this is promising work to be moved forward as rapidly as possible to address the tragic human disease ALS.”

 

ProMIS also notes the progress made in targeting another ALS/FTD target called RACK1 (receptor for activated C kinase 1). ProMIS’ encouraging preclinical data implicating RACK1 in ALS were presented recently as a poster at the American Academy of Neurology in Seattle, entitled “RACK1 Knockdown Alleviates TDP-43-Associated Global Translational Suppression in vitro and Neurodegeneration in vivo.” 

 

About ProMIS Neurosciences

 

ProMIS Neurosciences, Inc. is a development stage biotechnology company focused on discovering and developing therapeutics selectively targeting toxic misfolded oligomers implicated in the development and progression of neurodegenerative diseases, in particular Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD). The Company’s proprietary target discovery engine is based on the use of two complementary computational modeling techniques. The Company applies its molecular dynamics, computational discovery platform -ProMIS™ and Collective Coordinates – to predict novel targets known as Disease Specific Epitopes on the molecular surface of misfolded proteins. ProMIS is headquartered in Toronto, Ontario, with offices in Cambridge, Massachusetts. ProMIS is listed on the Toronto Stock Exchange under the symbol PMN, and on the OTCQB Venture Market under the symbol ARFXF

 

To learn more, visit us at www.promisneurosciences.com, follow us on Twitter and LinkedIn

 

For Investor Relations please contact:

Alpine Equity Advisors

Nicholas Rigopulos, President

nick@alpineequityadv.com

Tel. 617 901-0785

 

The TSX has not reviewed and does not accept responsibility for the adequacy or accuracy of this release. This information release contains certain forward-looking information. Such information involves known and unknown risks, uncertainties and other factors that may cause actual results, performance or achievements to be materially different from those implied by statements herein, and therefore these statements should not be read as guarantees of future performance or results. All forward-looking statements are based on the Company’s current beliefs as well as assumptions made by and information currently available to it as well as other factors. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this press release. Due to risks and uncertainties, including the risks and uncertainties identified by the Company in its public securities filings, actual events may differ materially from current expectations. The Company disclaims any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.

 

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